US Patent, No: 6846916
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United States Patent: 6,846,916
Obaje: January 25, 2005
Trans-acidolysis process for the preparation of carbohydrate fatty-acid esters
Abstract
The present invention relates to a low temperature, solvent-free trans-acidolysis process for preparing surface-active carbohydrate fatty-acid esters comprising the steps of: (e) reacting acylated carbohydrate with free fatty acid in the presence of acid catalyst, under reduced pressure, and without adding any solvent; (f) decolorizing and separating the reaction mixture obtained in step (a) into unreacted fatty acid layer and a carbohydrate fatty-ester layer; (g) precipitating out the unreacted acylated carbohydrate; (h) librating the hydroxyl groups by partial hydrolysis in the presence of an acid catalyst; (i) removing the unreacted free fatty acids and unreacted carbohydrate esters of low molecular-weight carboxylic acids during purification, and recycling the removed unreacted free fatty acids and carbohydrate esters to the starting reactant mixture.
Inventors: Obaje; Olobo Jonathan (Singapore, SG)
Assignee: URAH Resources Ltd.
Appl. No.: 050402
Filed: January 15, 2002
Foreign Application Priority Data
Feb 24, 2001[SG]: 200100727-7
Current U.S. Class: 536/18.6; 536/18.5; 536/115; 536/116; 536/119; 536/120; 536/124
Intern'l Class: C07G 003/00; C07H015/00; C07H017/00
Field of Search: 536/18.5,18.6,115,116,119,120,124
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Japan Patent, No.: 4580234
Singapore Patent.: SG 102614
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URAH is a Singapore Life-Science Research Company that has Developed and patented technologies for the delivery of active molecules through the skin barriers to biological targets. URAH Research Lab based at the Innovation Centre of Nanyang Technological University, Singapore, has transformed a number of Academic Researches into innovative Products & Services that are now in the Market.
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